Leveraging knowledge of Asian herbal medicine and its active compounds as treatment and prevention of COVID-19

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This article was originally published here

J Nat Med. October 8, 2021. doi: 10.1007 / s11418-021-01575-1. Online ahead of print.

ABSTRACT

The COVID-19 epidemic has led to the search for effective vaccines or drugs. However, insufficient vaccine supplies to meet global demand and the lack of effective and approved prescribed drugs for COVID-19 have led some people to consider the use of alternative or complementary medicine, such as traditional medicine to herbal. Medicinal plants have various therapeutic properties which depend on the active compounds they contain. Clearly, herbal medicine has played a vital role in treatment and prevention during the COVID-19 outbreak, especially in Asian cultures. Therefore, we have reviewed the uses of herbal medicine in Asian cultures and described the main families and species that are sources of antiviral agents against COVID-19 based on case reports, community surveys and available guidelines. in the literature databases. Antiviral efficacy as determined in laboratory tests has been evaluated, and several promising active compounds with their molecular targets in cellular models against viral infection with SARS-CoV-2 will be discussed. The results of our review revealed the very frequent use of members of the Lamiaceae family, Zingiber officinale and Glycyrrhiza spp. as medicinal sources for the treatment of COVID-19. In addition, several plant bioactive compounds derived from traditional herbal medicine, including andrographolide, panduratin A, baicalein, digoxin and digitoxin, have shown potent antiviral activity against SARS-CoV-2 compared to some reused drugs. FDA approved. These commonly used herbs and promising compounds are recommended for further exploration of their safety and efficacy against COVID-19.

PMID: 34623617 | DOI: 10.1007 / s11418-021-01575-1


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