Discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro

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J Nat Med. January 10, 2022. doi: 10.1007 / s11418-021-01596-w. Online ahead of print.

ABSTRACT

The emergence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic in 2019 led to a global health crisis. Mutations in the SARS-CoV-2 genome have hampered the development of effective treatments and vaccines against SARS-CoV-2. Natural products are important in finding therapies to treat coronavirus disease 2019 (COVID-19). In the present study, we investigated the antiviral activity of herbal extracts from polygala root, areca nut and quercus bark and natural compounds derived from herbal remedies such as baicalin and glabridin, with IC50 values ​​of 9.5 µg / ml, 1.2 µg / ml, 5.4 µg / ml, 8.8 µM and 2.5 µM, respectively, against SARS CoV-2 infection in vitro. Certain herbal extracts and natural compounds inhibit viral RNA levels and infectious titers of SARS-CoV-2 in a dose-dependent manner. In addition, viral protein analyzes have shown that herbal extracts and natural compounds effectively inhibit SARS-CoV-2 in the various entry treatments. Our study found that three herbal drugs are good candidates for further in vivo and clinical studies.

PMID:35006524 | DO I:10.1007 / s11418-021-01596-w

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