Current Use and State of Research on the Traditional East Asian Herbal Treatment for Multiple Sclerosis: A Scope Review


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Neurol before. Oct 18, 2021; 12: 710769. doi: 10.3389 / fneur.2021.710769. Electronic collection 2021.


Background: Multiple sclerosis (MS) is an immune-mediated chronic inflammatory disease of the central nervous system that is gradually increasing in prevalence. The etiology of MS remains unknown; however, it is believed to be caused by a deterioration in autoimmune regulation. Although immunomodulatory agents are a standard treatment option in patients with MS, there is insufficient evidence for their clinical efficacy in symptomatic treatment, and many patients with MS resort to complementary and alternative medicine. For this reason, we conducted a scoping study to investigate the current state of clinical evidence related to traditional East Asian herbal treatment for MS and to inform future research and treatment strategies. Method: A scoping review is an emerging methodology for knowledge synthesis that adopts the Arksey and O’Malley framework. The research question was: “What has been studied about herbal treatments given to patients with MS?” »Articles published up to 2019 were identified in six databases (PubMed, Embase, Cochrane, KoreaMed, NDSL and OASIS) as of March 2020. Data from included studies were listed and analyzed descriptively against the questions. study research. Results: Of the 1,445 articles identified, 14 studies were included in this review. Single and serial case reports made up the majority (42.86%), with 57.14% of studies conducted in China. A total of 20 prescriptions containing 95 herbs were used in the intervention and observational studies. Herbal remedies were effective in improving clinical symptoms of MS and reducing the frequency of recurrence. The main cause of MS was believed to be oxidative stress, which increases inflammation and, therefore, causes neuronal death. Conclusion: Herbal remedies have been shown to improve the symptoms of MS and reduce the frequency of recurrence. This study suggests that herbal remedies hold promise and are worth pursuing further studies, but the current state of the evidence is poor. Thus, further high quality studies including larger randomized trials are needed.

PMID: 34733228 | PMC: PMC8559786 | DOI: 10.3389 / fneur.2021.710769


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