Chinese Herbal Medicine SS-1 Proven Effective In Sjögren’s Mouse Study

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A Chinese herbal medicine called SS-1 may reduce inflammation and improve saliva flow, possibly due to an inhibitory effect on dendritic cells, a component of the innate immune system, according to a recent study on a model. murine Sjögren syndrome.

The study, “Effect of Chinese Herbal Medicine SS-1 on Sjögren’s Syndrome-like Disease in Mice, ”Was published in the journal Life.

Sjögren’s syndrome is an autoimmune disease in which a misguided immune response backs up against the glands that produce tears and saliva, resulting in dry eyes and mouth.

The disorder currently lacks disease-modifying drugs, with patients relying instead on therapies that relieve symptoms. Although some patients research Chinese herbal remedies, there is no scientific evidence that they can effectively treat Sjögren’s disease.

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In a previous clinical trial (NCT02110446), researchers affiliated with the China University Medical Hospital in Taiwan, along with several other Taiwanese institutions, investigated the potential of SS-1 – a herbal formula whose ingredients have anti-inflammatory, immunomodulatory and antifibrotic properties. effects – as a treatment for Sjögren’s syndrome.

The trial confirmed the therapeutic benefits of SS-1 in patients, but the mechanisms leading to such positive effects remain unknown.

To answer this question, the same team looked at the effects of SS-1 in a mouse model with experimental Sjögren syndrome. The disease was induced by injecting animals with submandibular salivary gland protein, which mimics or “recapitulates the main characteristics of humans.” [Sjögren’s syndrome]The researchers wrote.

Two weeks after disease induction, the animals were randomly assigned to receive SS-1 or water, administered orally twice daily for approximately 1.5 months.

The results showed that, compared to water, treatment with SS-1 significantly increased saliva flow and reduced the number of antibody-producing immune cells that infiltrated the saliva-producing submandibular glands.

It also significantly reduced the number of inflammatory cytokines – small molecules used by immune cells to communicate – found in the salivary glands of mice and limited the growth of immune T cells that produce them. These molecules tend to be overproduced in Sjögren syndrome.

The researchers studied the effect that SS-1 might have on anti-SSA and anti-M3R antibodies, which play a key role in Sjögren syndrome. Although the treatment reduced the amount of anti-M3R antibodies, it had no significant effect on those against SSA.

The team also noted that dendritic cells, a component of the adaptive immune system, matured less in response to SS-1 treatment. As these cells mature, they become able to activate immune cells that produce inflammatory cytokines associated with Sjögren syndrome.

The therapeutic effect of SS-1, they suggested, could be related to its ability to partially prevent dendritic cell maturation, thereby suppressing downstream cytokines.

“These results,” the researchers concluded, “indicate that SS-1 treatment may be an effective and safe therapeutic strategy and may be used as an immunomodulator for T cell-mediated autoimmune diseases, including [Sjögren’s syndrome]. “


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