Asian ancient herbal remedies may offer relief to veterans with Gulf War disease

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Andrographolide is a labdane diterpenoid that has been isolated from the stem and leaves of Andrographis paniculata plant.

Andrographolide, a herbal medicine popular in Southeast Asia, could restore gut microbiomes and viromes that have been altered by chronic, multiple symptom diseases like Gulf War disease (GWI) according to one University of South Carolina Environmental Health and Disease Laboratory study.

The study found that Andrographolide was successful in restoring bacteriomas and viromes while increasing beneficial bacteria and decreasing harmful bacteria. The treatment also decreased intestinal inflammation and neuroinflammation.

“Andrographolide, which is widely used in India and China, has been in use for ages and has many beneficial effects on liver disease and gastrointestinal disorders,” says Punnag Saha, a second-year doctoral student in the Department of environmental health sciences and principal investigator. for study. “Scientists have conducted significant research into its beneficial properties on various disease models, including the antiviral properties it possesses; However, the effectiveness of andrographolide on the various conditions associated with chronic multiple symptom diseases has never been studied.

The documented benefits of andrographolide prompted the UofSC Environmental Health and Disease Lab to determine if it could restore the altered gut microbiome / virome and relieve other symptoms associated with GWI and similar conditions.

Saurabh Chatterjee, director of the Environment and Disease Laboratory at UofSC, identified how microbiomes altered by GWI produce endotoxins that pass through the thinned wall of the intestine (i.e. leaking) and enter the bloodstream where they travel throughout the body, including the brain.

Andrographolide – a broad-spectrum antibacterial, antiviral, and anti-inflammatory compound – may not only relieve chronic symptoms typically associated with the disease, but may alleviate complications and vulnerability to co-infections, such as COVID-19[female[feminine. The authors recommend that clinical trials with GWI veterans be conducted to better determine the effectiveness of this treatment.

“The quest to identify new pathways in pathophysiology and target them with compounds derived from natural or botanical products remains a top priority for our research,” said Chatterjee. “Punnag and Dipro exemplify my lab’s continued quest to excel in fulfilling the mission of our department and the Arnold School of Public Health. The nationwide lab collaborators and Dr. Lim’s lab at Arizona State University are key to these discoveries.

Reference: “Andrographolide Alleviates Gut-Brain Axis Associated Pathology in Gulf War Disease by Modulating Bacterioma-Viroma-Associated Inflammation and Pro-inflammatory Microglia-Neuron Crosstalk” By Punnag Saha, Peter T. Skidmore, LaRinda A. Holland, Ayan Mondal, Dipro Bose, Ratanesh K. Seth, Kimberly Sullivan, Patricia A. Janulewicz, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Efrem S. Lim and Saurabh Chatterjee, July 9, 2021, Brain sciences.
DOI: 10.3390 / brainsci11070905

This study was supported by DoD-IIRFA grant W81XWH1810374, VA Merit Award I01CX001923-01, NIH grant 2P20GM103641 to Saurabh Chatterjee, and NIH grant R00DK107923 to Efrem S. Lim. This work was supported in part by an I01CX001923-01 Merit Review Award from the Clinical Sciences Research and Development Service of the United States Department of Veterans Affairs (US).


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